Groundbreaking scientist Georgios Papanikolaou, who would have turned 136 years a few days ago was honored with the May 13 Google Doodle which celebrated both his birthday and his life-changing invention; the Pap smear. Did you know that the medical fraternity has brought forth many brilliant minds, but very few can rival the impact that Papanikolaou has had on universal health? So far the Pap smear screening has prevented an average of 300,000 cervical cancer cases in the United States alone over the past thirty years.
Who invented the smear test?
Georgios Papanikolaou’s baby steps towards this invention started at Cornell University in the late 1910s while he was researching to find proof that the X and Y chromosomes actually determined an offspring’s sex. To complete his research, he had to extract eggs from guinea pigs, which were just on the eve of ovulation.
Unfortunately, at that time, there was no clear way of telling when an animal was ovulating. So, to make headway, he walked into a surgical supplies store and bought a nasal speculum (generally used by physicians to widen a patient’s nostrils for examination) which he used to collect vaginal secretions from guinea pigs and smear them microscopic slides.
“There were moments of real excitement when the examinations of the first slides revealed an impressive wealth of diverse cell forms and a sequence of distinctive cytologic patterns,” he wrote.
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If you do any searching today on Google, you’re notice they are honoring Georgios Papanikolaou, a Greek pioneer in #cytopathology and inventor of the “Pap smear” cervical cancer test. A test that is still widely used today for early detection of cancer. – – – Did you know? 🤔 — Past faculty member, Dr. Bernard Naylor, worked under Dr. Papanikolaou (shown in the group image on the last slide). Small world, right? #georgiospapanikolaou #papanikolaou #papsmear #pathology #researcher #research #earlydetection #cancer #umichpath #umichmedicine
Thrilled by the results, Papanikolaou’s wife, who also served as his principal assistant, volunteered her vaginal specimen to undergo the same procedure. The couple saw similar patterns to those in guinea pig specimens and set on a mission to publish comprehensive studies regarding the changes in vaginal smears about both ( woman and guinea pig ) reproductive cycles.
Why Pap smear is done?
Roughly 2.5 centimeters long, the cervix forms the lower part of the womb or uterus. It is the central canal to the vagina, which makes the way out of the body. Since it forms an entry point to the womb, the cervix has to remain firmly closed to retain and protect the developing baby during pregnancy.
It is made up of different microscopic cells that have a short lifespan. When required by the body, these individual cells divide to produce new ones, but in some cases, the process fails to cause the cells to divide unnecessarily. In this case, abnormal cells may grow, leading to the formation of a malignant or cancerous tumor.
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You are SO kind 💜 your msgs and doorstep drops, offers to catch up, I do reply but I thought I'd also do this! So what's it like on chemo at the mo? Firstly it's cumulative in my system so my good days didnt happen at all last round. It is a week since chemo now, it's very tricky to eat and digest things, my joints are sore and I'm trying to describe the fatigue bombs that drop, its building up inside so rather than on the 'home stretch' the days are longer so are the nights, and it's going to be worse than ever for the next 6 weeks or so.This is me 18-22 hours a day. Mark puts it that I just lie around the house all day doing IV drugs 🤣. I haven't read a book or watched an entire movie since May because 🤪 🤯 The hair loss and skin etc, now it's so much change that I watched my psychologist walk around reception cos she didnt recognize me yesterday. I'm showing me in this for you and other people who go through it bearing in mind I'm on a high dose double chemo, same regime as lung and bowel so it's not the same for all cancers.Even as it's gone along I had no idea how this was going to play out, and I want the conversation to help make it less invisible shameful and lonely to be bald and sick, and help normalize the cancer thing. You know it makes a massive difference when somebody gives me a really big smile out on the street so next time you see someone in a scarf gave them a big grin and a thumbs up 👍🏻🙃😘 So many people you know face this and more will. It's fine, and everything is ok I'm going to be good and I get an ok hour or two every day 💪🏻👍🏻 I did a board meeting by teleconference on Tuesday… but it's quite full on I thought it would be less bad, but I'll be a potato head druggy for a while yet. . . #ovariancancer #womancancer #tealsisters #chemotherapy #cancerfight #grateful #ovarcome #screwcancer #fuckcancer #savethebox #ladyballs #rosiegivesthanks
As the problem advances, these abnormal cells tend to separate and flow away through the circulatory system to other parts of the body through a process also known as metastasis. While in other parts of the body, they continue to develop into other forms of cancer.
It is because of these risks that a Pap smear test is recommended at regular intervals for you to rule out any chances of growth.
The first detection of cancer cells
While examining vaginal smears at a local hospital in 1925, Georgios Papanikolaou detected cancer for the very first time in a cervical smear. “That was one of the most thrilling experiences of my scientific career,” he said
The top medic moved on to recruit more women with cancer and presented his findings at a conference 1928
At that time, the New York World reported that although Dr. Papanikolaou was not ready to envisage how useful the new diagnostic method would be in the actual treatment process, it was so clear that it would help detect cancer at earlier stages where it could be fought off effectively.
Surprisingly, the test received minimal attention until ten years later.
Save your life through early screening
After years of skepticism, a clinical trial was finally commenced in 1939. To begin with, Papanikolaou interpreted several women’s vaginal smear at the New York Hospital and detected a significant number of early cancers that could not have been recognized by any other means. He then spent the next ten years, demonstrating the validity of the tests as he trained his colleagues to interpret the slides as well.
The first ever mass screening initiative was launched in Tennessee, Shelby County in 1952, where over 100,000 were screened.
Cancer was detected in 773 women
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𝕀 𝕓𝕣𝕠𝕦𝕘𝕙𝕥 𝕞𝕪 𝕞𝕠𝕥𝕙𝕖𝕣 (𝕚𝕟 𝕝𝕒𝕨) 𝕥𝕠 𝕨𝕠𝕣𝕜 This month, my mother and my mother in law (they happened to be very close friends) visited Philadelphia from the Netherlands. And since they were very curious about my new lab, I brought them with me on a Sunday (I had to count cells anyway, determine the cell doubling time of newly acquired cell lines). Mums are gonna be mums, so she made an awful lot of pictures while in the tissue culture ♡ #scientist #cellculture #bringyourmumtowork #bringyourmumtothelab #cancercells #postdoc
Today, the Pap smear test is recognized as one of the most defining milestones in the control and management of cancer in the 20th century. In the UK alone, cancer screening prevents over 2000 cervical cancer-related deaths, and since the country rolled out the programme in the 1980s, the incidence of cervical cancer has diminished by half.
Kudos if you form part of this success story!
You may be wondering, is it painful to have a Pap smear? Well, technically a Pap smear shouldn’t hurt at all because it is a simple process that has more to do with vaginal sample extraction. It can, however, get a bit uncomfortable due to the invasion into your privacy. It also feels awkward, but thankfully, it doesn’t take long.
George Papanikolaou’s short bio
- Born: May 13th 1883 in Kymi Greece
- Died February 19th 1962 in Miami Florida , US
- Nationality : American / Greek
- Education : Ludwig Maximilian University, Munich and more
- Spouse: Andromahi Mavrogeni
- Awards: Lasker-DeBakey Clinical Medical Research Award and more
George Papanikolaou hailed from a coastal town known as Kymi in Greece. He was born on May 13, 1883 and received his medical degree from the University of Athens in 1904. Here-after, he moved on to take his Ph.D. at the University of Munich in Germany after which he also attended some classes at the universities of Freiburg and Jena.
In 1910 Papanikolaou went back to Athens and got married to Andromahi Mavrogeni and then moved on to Monaco where he got a job at Oceanographic Institute of Monaco
Perhaps Papanikolaou’s most significant boost in his medical endeavor happened when studied under August Weismann and Ernest Haeckel; the two very influential biologists of the 20th century while taking his Ph.D. in Germany. The duo’s impact influenced him to devote himself to intensive biological research fully.
After many other feats and exploits in the field of medical research, he was declared the winner of the Nobel Prize in 1960 for his achievements on the smear test. The medical legend died in 1962 out of heart attack just before the opening of a Miami institute that was named in his honor.
Today, many more women are escaping the cancerous death trap to live their lives to the full thanks to Dr. Papanikolaou’s Pap smear test. It is such a simple test which has provided grounds for cervical cancer screening for many years. Furthermore, it can also be used to identify other diseases within the female reproductive system.
Pap smear today
Although the Pap smear test is still applied all over the world for early cancer detection, some countries like Australia are using a method that does not require the creation of a smear. They instead use one that targets the human papillomavirus HPV, which is one of the chief causes of cervical cancer.
These advanced methods extend to other countries like Scotland where the routine school girls’ vaccination against the human papillomavirus (HPV) has led to a significant reduction in cervical cancer in the young women’s later life.
Owing to advancement in medical technology, most ladies planning to go for a Pap smear are asking, Can Pap smear detect HPV? Well, there are two closely related tests;
- The Pap smear test
- The Cervical screening test
The first one is used to detect abnormal cells growing in the cervix while the second one helps to identify HPV infection.
Certain strains of sexually transmitted HPV have been directly linked to cervical cancer, which is quite prevalent among women below the age of 35 in the UK. Just ten years ago, the UK government launched a United Kingdom-wide immunization programme targeting girls on the eve of their teenage.
Cancer is mostly passive in its formative stages, and as such, it may not be possible to tell whether you have it or not. As earlier mentioned, a regular Pap smear test would be the surest way to determine your status.
However, when you notice unusual symptoms like vaginal bleeding, (after sexual intercourse and between periods), Pelvic pain, post menopause bleeding and smelly vaginal discharge, chances are you have cervical cancer.
Remember Georgios Papanikolaou and go for the Pap smear test.